![]() ![]() ![]() ![]() Projects: These are your saved projects and any subfolders you’ve created in OmniPlan.īeneath the On My folder on the locations screen, you’ll see one or more options for adding locations to the list of document sources available to OmniPlan.MS Project Support: A preview document for the Microsoft Project file import feature, available with the OmniPlan Pro in-app purchase.By default, the projects you create are sorted by their creation date, or you can opt to sort them by title. Sort: When you pull down on the screen, the super secret Sort bar comes into view.For example, you can select one or more documents and move them to another folder, to the trash, or create a subfolder within the current folder that contains the projects you’ve selected. Select: Tap to edit the contents of a folder.Settings: Tap to reveal a menu with preferences for OmniPlan, as described in Settings.Your default folder for storing files locally is titled On My, and the document type is Plans (this is currently the only document type available). Folder Name and Document Type: This is the name of the current folder.Locations: Tap here to go back to the main screen where you can view the On My folder and any server repositories you’re synced with.This opens the Document Browser, which is the place to view, create, and manage your projects. Tap the On My folder to see what’s inside. There is an On My folder, which we’ve preloaded with some sample OmniPlan files that you can use as inspiration for the projects you create. When you first open OmniPlan, you’re taken to the Locations screen which is the place you go to access all of your documents. ![]()
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![]() ![]() There's little in its open-world that feels like a chore - something you can say about few open-world games. While some of Elden Ring’s optional dungeons are a bit rote, just as often, you'll stumble into one with a wild boss fight or a series of joke design choices that lead to laugh-out-loud twists. ![]() You'll stumble into a dungeon with a wild boss fight or a series of joke design choices that lead to laugh-out-loud twists. Underneath all of Elden Ring’s lore and world design, there’s a simple joy to smashing enemies with a big sword underneath all of Elden Ring's lore and world design. ![]() You can now even bring summonable monsters to battles, Pokemon style. There is a wealth of options for specializing your character, with many weapons and spells to support your play style. You want to make sure you are ready and blocking their attack or not in the path of their weapon at all. Frantically attacking will leave you tired and vulnerable in the path of enemies who hit hard, slicing your health bar to nothing in just a few strikes. You need to manage your stamina, picking your moment to strike or dodge. The combat fundamentals are as strong as ever. Veterans of FromSoftware will find themselves at home in Elden Ring quickly. Publisher Bandai Namco and FromSoftware have released performance patches to resolve these issues. Still, these are a nuisance in a game where you want no distractions in its brutal boss battles. It's frozen more than once, too, but it’s not stopped us from playing. While we have run into a smattering of performance issues, these weren’t game-breaking - occasional stuttering and frame drops. There is a heavy metal album cover for every grandiose landscape of somber, mournful contemplation or a giant tortoise who hands out history lessons. The skeletons could have stepped right out of Jason and the Argonauts. The tone shifts between the epic fantasy of Lord of the Rings to popcorn adventure of 80s movies like Excalibur or The Neverending Story. ![]() Perhaps a vain hope, but finding out for sure drove us to seek out its far corners.įor all its portent and doom, Elden Ring has moments of silliness, too. Unlike FromSoftware’s other games, set in dying worlds, in Elden Ring it feels like maybe, just maybe, you can save this world. It's a rumination on how the powerful suffocate the world to sustain their reigns. After 70 hours with the game, most of its story still exists as a hazy collection of themes. Exploration leads to real discovery, unraveling the world’s mysteries and machinations. The fact that it's almost impossible to answer the simple question "what is an Elden Ring?" at the game's start speaks volumes for its intentions. Of course, that's what you're told to do - learning what's really going on and what other paths exist is the real treat of this game. You're a Tarnished, a forgotten warrior tasked with ascending to the role of Elden Lord, to repair the Elden Ring, and maybe restore order to the world. Elden Ring sees you charging over hills strewn with giants under the glow of a skyscraping, glowing tree. It's a rumination on how the powerful suffocate the world to sustain their reigns.ĭark Souls and Bloodborne see you wading through dying streets and sewers. The main menu music sets the stage, starting with foreboding notes before diving into loud brass that conjures up the more grandiose adventure that awaits. While lovers of messed-up fantasy lands will get their kick, Elden Ring is a notably colorful and slightly more friendly place to roam. (Image credit: Bandai Namco Entertainment) ![]() ![]() ![]() We support Steam Workshop as the easiest way to deliver plenty of community-made mods to you.This is a fabulous game! I’m addicted! I love, love, love this app, but because of that, the bugs drive me crazy! It has several issues.1. The game is bundled with the always up-to-date modding tools. A lot of aspects can be modded: from changing existing config files to adding new vehicles and buildings, resources, production technologies, research, and any other supported content to writing custom logic using C#. Voxel Tycoon is developed with rich extensibility in mind. ![]() Higher demand leads to higher prices! As a last resort, you can always help cities and business solve their financial problems directly by investing funds in their development.ĭon’t just focus all of your efforts on freight - people have destinations to get to as well! Manage passenger flow between cities, and don't forget to treat them with care - different passengers are all heading to different places. Keep in mind that the values of goods are not constant and depend heavily on your actions as the supplier. The bigger a city gets, the more customers and passengers move in, meaning more potential profit! The growth of a city doesn't simply increase the quantity of goods required - higher stages of development will move away from the basics, requiring more complex and expensive products. EconomyĮvery city has its own needs, which you can fulfill to kick-start growth. Fly around in the first person for gorgeous views, get a closer detailed look at production chains, and even ride around on your trains while they do their job. The world is not limited to the classic top-down Tycoon view - Free Camera mode allows you to immerse yourself directly into the action. The world is endless, so you’ll never run out of space.įor the most successful tycoons, we include full-featured terraforming: turn the world into exactly what you want, all according to your perfect plan! Keep in mind, however, it might cost you a fortune. Unlock new regions to find rare resources and new development opportunities. Infinite WorldĮxplore an unlimited, procedurally-generated world filled with unique biomes, from deserts to arctic tundra. Organize mining with mine shafts, then process the raw materials using crushers, furnaces, refineries, and other machinery.Ĭomplex production chains require complex logistics! Design unique factories of your very own by connecting machinery, buildings, and storage facilities with conveyor belts.įund and supply research of new technologies, unlocking new buildings, production chains, and vehicles. You can give mass orders using Routes, or set up individual tasks for each vehicle on your roster.īridging and tunneling, along with a full signaling system (you don't want your trains to crash into each other, do you?), allow you complete freedom to build and expand your network. ![]() ![]() Thanks to our physics simulation, vehicles will behave differently based on their weight, the type and amount of cargo they're carrying, motive power, and grades.įlexible scheduling allows, among other things, to select exact tracks where trains should arrive at stations, or choose what specific railcars should load or unload at any given stop. The game has more than 50 vehicles representing eras from steam to electric, among which are locomotives, railcars, trucks (including semi-trailers!), buses, multi-unit speed trains, and more.Įvery vehicle has its own unique properties that you should take into account when buying and building consists of them. Set up supply chains and passenger routes with a huge fleet of trains, trucks, and buses, and turn small towns into prosperous megacities with a thriving economy! Transportation Mine resources and process them into goods on your custom factories. Voxel Tycoon - a management sim set in the infinite voxel world. ![]() ![]() ![]() Interns from all sponsoring institution programs participated, identifying, mitigating, and reporting a range of patient safety hazards. We designed and implemented an escape room patient safety simulation to incorporate active learning, gamification, and adult learning theory into intern patient safety onboarding. Demonstrating the rationale and mechanics of reporting may improve this. Together these results illustrate that NS escape populations are produced by replication of partially drug resistant viruses in the CNS and suggest that evolution of escape virus is facilitated by elevated CSF WBCs and an impaired ability of the immune system to control viral replication.Although residents are on the front lines of patient care, they enter few formal patient safety reports on the adverse events and near misses they witness. The escape viruses remaining T cell-tropic despite replication and evolution in the CNS suggests that they primarily replicate in CD4+ T cells. In addition, profound immunosuppression prior to ART was associated with escape populations with higher genetic diversity likely due to persistent replication in the CNS of these participants. All escape viruses examined (N=25 from 10 participants) were T cell-tropic.Ĭonclusion: Observed genetic diversity, drug resistance and resolution of symptoms after ART optimization indicate that NS escape is produced by replication of partially drug resistant virus in the CNS of ART-treated participants. 97% of escape populations were at least partially resistant to their ART regimen and, of those, 94% saw symptoms improve after ART optimization. Participants with the most diverse populations also had lower nadir CD4 counts compared to those with single lineages (t test, p = 0.04). CSF NS escape populations either had one major lineage (47%), two major lineages (33%) or a highly diverse, recombinant population (16%). ![]() The median blood CD4 count was 471 cells/ul, nadir CD4 count 98 cells/ul, and CSF white blood cells (WBC) 21 cells/ul. Results:Median CSF and plasma VLs were 2,400 and 140 copies/ml, respectively. Pairwise distances of partial envs were calculated. Full-length env genes were cloned from the CSF of 10 participants and their ability to enter cells expressing a low density of CD4 (a predictor of macrophage tropism) was assessed. We used single genome amplification (SGA) and/or Illumina MiSeq deep sequencing with Primer ID to asses genetic diversity in partial env sequences (V1-V3) and drug resistance in PR, RT, and IN. Methods: We examined viral populations in blood plasma and CSF from people with NS CSF escape (neurologic symptoms with CSF viral load (VL) >40 copies/ml, and CSF VL > plasma VL, n=36). ![]() The cellular source of NS escape virus is unknown. Joseph1 1University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 2Poona Hospital and Research Center, Pune, India, 3San Raffaele Scientific Institute, Milan, Italy, 4University of Turin, Turin, Italy, 5Yale University, New Haven, CT, USA, 6University of Gothenburg, Gothenburg, Sweden, 7University of California San Francisco, San Francisco, CA, USAīackground: Neurosymptomatic (NS) cerebrospinal fluid (CSF) escape occurs in people living with HIV-1 who present with neurologic symptoms and have elevated HIV-1 RNA in their CSF despite being on antiretroviral therapy (ART) and having undetectable or low levels of HIV-1 RNA in the blood. Spudich5, Magnus Gisslen6, Richard Price7, Sarah B. Dravid2, Paola Cinque3, Mattia Trunfio4, Andrea Calcagno4, Serena S. NEUROSYMPTOMATIC HIV-1 CSF ESCAPE ASSOCIATES WITH REPLICATION IN CNS CD4+ T CELLS ![]() |